Automatic Synthesis of Ethyl 18FFluoroacetate and its first PET imaging
(0) 18FFDG has been the most widely used as the PET tracer for detecting brain and systemic tumors, however, 18FFDG uptake in adjacent normal brain tissue is so strong that 18FFDG-PET imaging could not give an effect for brain functional imaging. In order to develop new PET radiopharmaceuticals to complement 18FFDG, a simple method for automatic synthesis of ethyl 18Ffluoroacetate which can be operated in a commercial synthesizer has been established. The simple preparation of ethyl 18Ffluoroacetate was accomplished in a short synthesis time of 24 min and with a reproducible radiochemical yield of 41.4 ± 10.2％, (decay corrected), and high radiochemical purity more than 98％. The PET imagings of ethyl 18Ffluoroacetate and sodium 18Ffluoroacetate were obtained in marmoset brain. SUV of ethyl 18Ffluoroacetate in the brain was 1.6, which was about 2.6 times higher than that of sodium 18Ffluoroacetate. The present results showed that ethyl 18Ffluoroacetate should be an ideal tracer for brain PET imaging.
ethyl 18Ffluoroacetate PET imaging automatic synthesis brain functional imaging
Li-Quan Sun Tetsuya Mori Masato Kobayashi Hidehiko Okazawa Takako Furukawa Yasuhisa Fujibayashi
School of Life Science and Technology Beijing Institute of Technology Haidian District, Beijing, 100 Biomedical Imaging Research Center University of Fukui Eiheiji, Yoshida, Fukui, 910-1193, Japan
国际会议
上海
英文
2559-2562
2008-05-16（万方平台首次上网日期，不代表论文的发表时间）