The Effects of TDI on Mice Marrow Cells

摘要：

This paper is to study the effects of TDI on mice marrow cells. The effects of TDI were studied by laser scanning confocal microscope to investigate morphologic changing of the mice bone marrow cell and genotoxicity test --chromosomal aberration test and sister chromatic exchange(SCE) test. Results showed that the 1/16LC50 and 1/8LC50 dosage of TDI had no significant effects on the fluorescence pixels rate of RNA/DNA, the chromosome aberration rate and the frequencies of sister chromatic exchange of the mice(P>0.05), but both 1/4 LC50and 1/2 LC50 dosage had significant effects on the fluorescence pixels of RNA/DNA, and the chromosome aberration rate and the frequencies of sister chromatic exchange of the mice (P<0.01). TDI has the genetic toxicity.

关键词： Toluene Diisocyanate laser scanning confocal microscope DNA RNA chromosomal aberration sister chromatid ezchange

作者: JI Yubin JI Chenfeng LANG Lang YU Lei ZOU Xiang

作者单位: Center of Research and Development on Life Sciences and Environment Sciences Harbin University of Commerce Harbin, China

会议类型: 国际会议

会议名称: The 2nd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2008)(第二届生物信息与生物医学工程国际会议)

会议地点: 上海

会议语种:英文

页码: 4570-4572

在线出版日期: 2008-05-16（万方平台首次上网日期，不代表论文的发表时间）