Application of the lifetime positron spectroscopy for photodynamic therapy

摘要：

We discuss the perspectives of life-time method of positron spectroscopy applying to therapeutic antimicrobial photodynamic inactivation (PDI). The mechanisms of photodestructive influence onto bacterial cells are based on laser exposure 1 of photosensensitizer, binding in significant amounts to cell wall or cytoplasmic membrane, and generation of reactive oxygen species to induce an irreversible oxidative damage of the cellular critical targets. Some notions to develop positron annihilation spectroscopy (PAS) as a new noninvasive technique for the detection of molecular damage by UV radiation issued in 2 and references therein.

作者: L.V.Elnikova M.G.Strakhovskaya

作者单位: A.I.Alikhanov Institute for Theoretical and Experimental Physics,25,Bolshaya Cheremushkinskaya Stree M.V.Lomonosov Moscow State University,Faculty of Biology,Biophysics Department,Vorobievy Gory,Moscow

会议类型: 国际会议

会议名称: 第九届国际正电子与正电子素国际会议(9th International Workshop on Positron and Positronium Chemistry)(PPC–9)

会议地点: 武汉

会议语种:英文

页码: 121

在线出版日期: 2008-05-11（万方平台首次上网日期，不代表论文的发表时间）