CURRENT ADVANCES IN HIGH THROUGHPUT SNP GENOTYPING BASED ON HYBRIDIZATION ON MAGNETIC NANOPARTICLES

摘要：

Based on dual-color hybridization on magnetic nanoparticles, we have been continued to push the research on high-throughput single nucleotide polymorphism (SNP) discrimination for large sample sizes with a good many of SNP loci. Typically, in last two years, we have developed the multiplex single nucleotide polymorphisms genotyping using solid-phase single base extension on magnetic nanoparticles, a novel SNPs detection sensors based on magnetic nanoparticles array and dual-color single base extension, and an auto-MagStation for semi-automated and high-throughput SNP genotyping based on dual-color hybridization. In this paper, we will present the schemes and highlights of approaches mentioned above.

关键词： Single nucleotide polymorphism high-throughput magnetic nanoparticles dual-color hybridization single base eztension magnetic nanoparticles array.

作者: He Nongyue Deng Yan Liu Hongna Li Song

作者单位: The State Key Laboratory of Bioelectronics, Southeast University, 210096 Nanjing, China The Hunan Ke The State Key Laboratory of Bioelectronics, Southeast University, 210096 Nanjing, China

会议类型: 国际会议

会议名称: The 6th International Forum on Post-genome Technologies(6IFPT)(第六届国际后基因组生命科学技术学术论坛)

会议地点: 北京

会议语种:英文

页码: 48-50

在线出版日期: 2009-09-17（万方平台首次上网日期，不代表论文的发表时间）