Various para-substituted arylboric acids have been widely used in the fields of electronics, chemistry, medicine and biology. Therefore, it is very important to study the preparation and improvement of para-substituted phenylboric acids. In this thesis, the synthesis of two or three different para-substituted phenylboric acid and their improvements were studied in detail. The influencing factors such as temperature, reaction time, reactant molar ratio were analyzed with the orthogonal experiment, a optimized process for the preparation of 4 - tert -butylphenylboric acid (and 4 - isopropyl-phenyl-boric acid) was thus obtained using different alkylborate as original material. The final yield was 69. 5％ (and 56. 6％), the purity was 98. 0％. An optimized process for the synthesis of 4 - chlorophenyl-boric acid was also obtained using tri-n-butylborate as boronation reagent The final yield was increased from 62. 0％ to 87. 8％, the purity was 98. 0％. Meanwhile, the preliminary synthesis of 4 -bromophenylboric acid was investigated too. Each product was identified by MS, 1HNMR, IR and HPLC.
Hunan Key Laboratory of Green Packaging and Application of Biological Nanotechnology,Hunan Universit State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China Hunan Key Laboratory of Green Packaging and pplication of Biological Nanotechnology,Hunan University Hunan Key Laboratory of Green Packaging and Application of Biological Nanotechnology,Hunan Universit Hunan Key Laboratory of Green Packaging and Application of Biological Nanotechnology,Hunan Universit