A GRAVITY-ACTUATED TECHNIQUE FOR DROPLET MICROFLUIDICS
A gravity-actuated technique for on-demand microfluidic sampling, droplet generation, fusion, mixing and staying is first described. T-junction microchannel is designed and standard PDMS fabrication techniques are used to fabricate microchips. Both oil-phase and water-phase are driven only by controlling height difference of oil-phase with a turntable. Droplets of different size and spacing are easily obtained according to experiment requirement. Moreover two droplets with different size and composition are manipulated to perform high-efficient generation, fusion, mixing and staying to assay. The whole process doesnt need any syringe pump, needle, mechanical valve, electronic component and high-speed CCD. Therefore, this technique is very good to avoid the complicated and expensive chip fabrication and can be easily integrated into portable microdevice for a variety of droplet-based application mainly in biological/chemical assays and high content drug screening.
Microfluidic chip droplet gravity manipulation
Zhang Kai Liang Qionglin Wang Yiming Luo Guoan
School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China Key Labo Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education),Departm
国际会议
The 6th International Forum on Post-genome Technologies(6IFPT)(第六届国际后基因组生命科学技术学术论坛)
北京
英文
106-107
2009-09-17（万方平台首次上网日期，不代表论文的发表时间）