ASSOCIATION OF ESTROGEN RECEPTOR A GENE POLYMORPHISMS WITH HEPATITIS C VIRUS (HCV)-RELATED LIVER DISCASE
Objective: To investigate the relationship between estrogen receptor α (ERα) gene polymorphisms and Hepatitis C virus (HCV)-related liver disease. Mehtods: PVUII and Xba I polymorphisms of ERa gene were analyzed in 100 healthy controls and 403 HCV patients including 93 asymptomatic carriers, 115 hepatitis, 105 cirrhosis and 90 hepatocellular carcinomas (HCC) by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.Results- Pp genotype and Pallele genotype of ERa gene was over-represented in HCC patients as compared to carriers. Differences were more evident comparing HCC patients and carriers (57. 78％ w41. 94％.), with a twofold risk of HCC for the Pp patients (OR:2. 33; 95％CI: 1. 03 5. 58; P: 0. 03) , and with ter-fold risk of HCC for the P allele patients (OR-.3. 37; 95％CI-. 1. 53 5. 95; P: 0. 01). No differences were observed for pp genotype, pallele and Xba I gene polymorphisms.Conclusion: Pp genotype and P allele of ERa gene may be related to liver cancer risk in HCV-infected patients in Jiangsu province.
Estrogen receptor a Gene polymorphism Heptatitis C hepatocirrhosis Hepatocellular carcinomas
Yang Jingjing Zhang Yun Wang Haopeng Deng Xiaozhao Wang Jie Xu Ke
The institute of Militalry Medicine, Nanjing Command, Nanjing 210002, China Hohai University Departm The institute of Militalry Medicine, Nanjing Command, Nanjing 210002, China
国际会议
The 6th International Forum on Post-genome Technologies(6IFPT)(第六届国际后基因组生命科学技术学术论坛)
北京
英文
200-203
2009-09-17（万方平台首次上网日期，不代表论文的发表时间）