COMPARATIVE QUANTIFICATION OF MICRORNA IN PLACENTA AND CIRCULATING NUCLEIC ACID ISOLATED FROM MATERNAL PLASMA ANDUMBILICAL CORD PLASMA

摘要：

The purpose of this study was to analyze the miRNA expression in placenta, maternal plasma and umbilical cord plasma of patients with mild and severe preeclampsia vs. maternal plasma of normal pregnancies. Three families of miRNA was analyzed, which were miR-411, miR-154* and miR-18a. The miRNA expression was compared between mPE and sPE in the same kind of sample, and also among the three kinds of sample. The result showed that miR-411 and miR-154* were downexpressed and miR-18a was upexpressed. It also showed that the expression of miRNA in placenta was consistent with maternal plasma, but showed more significant change in maternal plasma of sPE vs. mPE. However, the expression of miRNA in umbilical cord plasma showed no markable relationship.

关键词： MicroRNA circuling nucleic acid preeclampsia

作者: Yang Qi Ge Qinyu Lu Jiafeng Li Hailing Lu Zuhong

作者单位: The State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096,China Key Laboratory of Child Development and Learning Science, Ministry of Education, Southeast Universit Zhongda Hospital, Southeast University, Nanjing, China The State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096,China Key Laborator

会议类型: 国际会议

会议名称: The 6th International Forum on Post-genome Technologies(6IFPT)(第六届国际后基因组生命科学技术学术论坛)

会议地点: 北京

会议语种:英文

页码: 224-228

在线出版日期: 2009-09-17（万方平台首次上网日期，不代表论文的发表时间）