DIRECT VISUALIZATION OF MICRORNAS BASED ON NON-CROSS-LINKING GOLD NANOPARTICLE AGGREGATION

摘要：

The hybridization between RNAs and oligonucleotide probes immobilized on gold nanoparticles (GNPs) can induce the non-cross-linking GNP aggregation accompanied by red-to-purple (or blue) color changes. This phenomenon is successfully applied to detect microRNAs (miRNAs) and as low as 5 nM miRNA can be detectable.

关键词： Gold nanoparticles non-cross-linking aggregation miRNAs visualization

作者: Li Zhengping Fan Yongshan Song Jinzhao Liu Chenghui

作者单位: Key Laboratory of Medicine Chemistry and Molecular Diagnosis, Ministry of Education College of Chemistry and Environment Science, Hebei University, Baoding 071002, China

会议类型: 国际会议

会议名称: The 6th International Forum on Post-genome Technologies(6IFPT)(第六届国际后基因组生命科学技术学术论坛)

会议地点: 北京

会议语种:英文

页码: 269-271

在线出版日期: 2009-09-17（万方平台首次上网日期，不代表论文的发表时间）