DYNAMIC CHANGES OF MICRORNA EXPRESSION IN MOUSE HIPPOCAMPAL AFTER TRAUMATIC BRAIN INJURY
Recent reports demonstrated that miRNAs play an important role in TBI pathophysiology. However, the miRNA functional mechanism involved in the complex course is little known. In the present study, we examined expression levels of eight microRNAs concerned with neurogenesis (mir - 124a, mir - 128, mir - 9, mir - 23a/b) , proliferation and differentiation (mir - 34a, mir - 7a, mir - 214) in the hippocampus after brain injury using quantitative polymerase chain reaction. We choose six time points post brain injury: 4 h, 12 h, 24 h, 48 h, 72 h and 7 d, respectively, to reveal dynamic changes of miRNAs expression in mouse brain hippocampus compared with control groups. Our results demonstrate that eight miRNAs were all up-regulated at the first 4 h. The expression levels of miRNAs showed significant changes, and reached the maximum expression levels at 72 h post injury. It is indicated that miRNAs regulation could be initially stimulated response to pathophysiology after TBI.
MicroRNA traumatic brain injury hippocampal
Ruan Qiongfang Wang Yang Pan Changfu Gao Faliang Kuang Zhucai Shen Xiaoli Zhifeng Deng
Institute of Urology, the First Affiliated Hospital of Nanchang University Department of Neurosurgery, the Second Affiliated Hospital of Nanchang University,Nanchang 330006,Ch
国际会议
The 6th International Forum on Post-genome Technologies(6IFPT)(第六届国际后基因组生命科学技术学术论坛)
北京
英文
282-285
2009-09-17（万方平台首次上网日期，不代表论文的发表时间）