EXPRESSION OF MIRNA-210 AND MIRNA-92A AFFECTED BY RENAL ISCHEMIA/REPERFUSION INJURY IN MICE
MicroRNAs are a group of small non-coding RNAs with modulator activity of gene expression. Recent studies have uncovered a profound role of microRNAs in ischemic diseases. This study aimed to investigate the potential expression change of miRNA-210 and miRNA-92a in kidney ischemia/reperfusion injury in mice. Quantitative Realtime RT-PCR analysis showed that ischemic kidney injury significantly increased miRNA-210 and miRNA-92a expression compared to the sham-operated controls, with prominent changes at 4 h and 24 h after recovery. ( n = 3 each, * P< 0. 05 vs. control) In conclusion, our data suggest that dysregulation of miRNA-210 and miRNA-92a expression may contribute to kidney ischemic disease.
Kidney Ischemia/Reperfusion injury miRNA Mouse
Wu Jue Liu Fen Ruan Qiongfang Xie An Lou Yuanlei Deng Jun Wang Yang
Institute of Urology, the First Affiliated Hospital of NanChang University, Nanchang 330006, China Institute of Urology, the First Affiliated Hospital of NanChang University, Nanchang 330006,China
国际会议
The 6th International Forum on Post-genome Technologies(6IFPT)(第六届国际后基因组生命科学技术学术论坛)
北京
英文
304-307
2009-09-17（万方平台首次上网日期，不代表论文的发表时间）