HCV F PROTEIN, UNLIKE CORE PROTEIN, CAN NOT REGULATE HTERT AND P53 PROMOTER ACTIVITIES
Previous results have suggested that HCV core protein transcriptionally regulates cellular and viral genes, such as human telomerase reverse transcriptase (hTERT) and p53, etc. Recent researchers identified a novel F protein that was synthesized from the initiation codon of the core protein followed by a ribosomal frame shift into the +1 reading frame. Then we evaluated the regulatory role of F protein on hTERT and p53 promoter by an in vitro transfection assay. The results revealed that the HCV core protein indeed caused up-regulation of hTERT and down-regulation of p53. However, F protein did not significantly relative to negative control. In conclusion, our results suggested that F protein can not regulate hTERT and p53 promoter, which were previously attributable to core protein expression.
Hepatitis C virus (HCV) F protein core protein human telomerase reverse transcriptase (hTERT) p53
Deng Xiaozhao Kong Jing Zhang Yun Wang Zhongchan Yu Juan Li Chunlei
Medical Institute of Nanjing Army, Nanjing 210002, China Medical Institute of Nanjing Army, Nanjing 210002, China Faculty of Life Sceince & Chemical Engineer
国际会议
The 6th International Forum on Post-genome Technologies(6IFPT)(第六届国际后基因组生命科学技术学术论坛)
北京
英文
336-339
2009-09-17（万方平台首次上网日期，不代表论文的发表时间）