LANTHANUM REGULATES GENE EXPRESSION OF PROINFLAMMATORY FACTORS: IN VIVO EXPERIMENTS

摘要：

Lanthanide ions have been proved to have various biologic effects. Lanthanum with extremely active physical and chemical property was evidenced to possess antibacterial effects and regulating cellular immunity. In the present study, the effects of lanthanum chloride on lipopolysaccharide (LPS) challenged mice were examined. Lanthanum chloride can greatly decrease the secretion of tumor necrosis factor α(TNFα) and Interleukin 1 β(IL- 1β) as well as TNFα mRNA expression in the mice challenged with LPS. To clarify the mechanism involved, the effects of Lanthanum chloride on the activation of nuclear factor (NF)- κB were examined in liver and in peritoneal macrophages. The LPS - induced activation of NF - κB was significantly blocked by lanthanum chloride. These findings demonstrate that the inhibition of the LPS- induced inflammatory media, such as TNFα and IL- 1β, by lanthanum chloride, is due to the inhibition of NF- κB activation.

关键词： Lipopolysaccharide Lanthanum Tumor necrosis factor Interleukin 1β Nuclear factor - κB

作者: Guo Fei Wang Yang Lou Y Lei Xie An

作者单位: Burns Institute, the first affiliated hospital of Nanchang University, Nanchang 330006, China Institute of Urology, the first affiliated hospital of Nanchang University, Nanchang 330006, China Institute of Urology, the first affiliated hospital of Nanchang University, Nanchang 330006,China

会议类型: 国际会议

会议名称: The 6th International Forum on Post-genome Technologies(6IFPT)(第六届国际后基因组生命科学技术学术论坛)

会议地点: 北京

会议语种:英文

页码: 357-361

在线出版日期: 2009-09-17（万方平台首次上网日期，不代表论文的发表时间）