LRRCA INHIBITS MOBILITY AND INVASION THROUGH THE SDF-1A/CXCR4 AXIS IN U251 CELLS
Glioblastomas are the most common and lethal human primary brain tumors, and are characterized by high invasiveness. SDF- 1α binds to CXCR-4 receptor and acts to modulate cell migration and proliferation. LRRCA is a potential glioma suppressive gene. The reexpression of LRRCA can significantly suppress glioblastomas U251 cells tumorigenesis in vivo and cell proliferation and invasion in vitro. In this study, we found that SDF-lα could increase the invasion in U251 expressed CXCRA . The reintroduction of LRRCA in U251 cells could inhibit the expression of CXCRA. LRRCA also inhibited the adhesion ability of U251 to ECV304 as well as the mobility and invasion ability in vitro, which are mediated by SDF-1α/CXCR4 axis. Further more, LRRCA can greatly enhance GJIC of U251 cells. Thus, the reintroduction of LRRCA in U251 cells could inhibit the expression of CXCRA and the SDF-1α/CXCRA axis-mediated cells invasion in vitro.
LRRC4 glioma SDF-1 CXCR4 invasion
Liu Enyi Tang Hailin Wang Rong Wu Minghua
Cancer Research Institute, Central South University, Changsha 410078, China
国际会议
The 6th International Forum on Post-genome Technologies(6IFPT)(第六届国际后基因组生命科学技术学术论坛)
北京
英文
362-366
2009-09-17（万方平台首次上网日期，不代表论文的发表时间）