PHYLOGENETIC ANALYSIS OF HUMAN OLFACTORY RECEPTOR SEGREGATING PSEUDOGENES
Humans have a total of 855 olfactory receptor (OR) genes which can be classified into class I and II genes, but more than 50％ are pseudogenes. A remarkable acceleration of such repertoire reduction has occurred in the primate lineage and this process is probably still ongoing. The evidence is the prevalence of segregating pseudogenes (SPGs) which segregate between an intact and pseudogene form in the human genome. It has been indicated that the evolution process of human OR genes is a process of birth and death. We investigated all the SPGs in the human OR genes and found that the selection pressures acting on the two classes in the human OR genes were different. The class I genes were more prone to pseudogenize and the birth process were more possible to occur in the class II genes. This may be explained that the class I genes recognizing water-soluble odorants become less important than the class II genes detecting airborne odorants because of the environmental change.
Olfactory receptor segregating pseudogenes birth and death evolution
Nie Yumin Sun Xiao
State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering, Southea State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southe
国际会议
The 6th International Forum on Post-genome Technologies(6IFPT)(第六届国际后基因组生命科学技术学术论坛)
北京
英文
400-402
2009-09-17（万方平台首次上网日期，不代表论文的发表时间）