THE EFFECTS OF REPETITVE TRANSCRANIAL MAGNETIC STIMULATION ON THE EXPRESSIONS OF BDNF, NMDAR1, SYN IN HIPPOCAMPAL CA1 AREA OF RATS MODEL WITH VASCULAR DEMENTIA
Purpose To study the effects of rTMS on the expression of BDNF, NMDAR1 and SYN in hippocampal CA1 area of rats model with VaD, and to further explore the molecular mechanism of the rTMS treatment on vascular dementia. Methods Rats were randomly divided into four groups. Low-frequency stimulation group rats were accepted 0. 5Hz rTMS for six weeks. High-frequency stimulation group rats were accepted 5Hz rTMS for six weeks. The expression of BDNF, NMDAR1 and SYN in hippocampal CA1 area were detected by immunohistochemistry. Results The expressions of BDNF, NMDAR1 and SYN protein in the stimulation groups were higher than that in the dementia model group (P<0. 05). Conclusion rTMS had a role in the restoration treatment of vascular dementia, which may be related to the mechanism that rTMS can increase the expressions of BDNF, NMDAR1 and SYN, and affect the synaptic plasticity in hippocampal CA1 area of the VaD rats.
Vascular dementia, repetitive transcranial magnetic stimulation brain-derived neurotrophic factor N-methyl-D-aspartate receptor synaptophysin
Wang Fei Geng Xin Tao Huaying Cheng Yan
Department of Neurology, General Hospital, Tianjin Medical University, Tianjin, China Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin, China
国际会议
The 6th International Forum on Post-genome Technologies(6IFPT)(第六届国际后基因组生命科学技术学术论坛)
北京
英文
444-448
2009-09-17（万方平台首次上网日期，不代表论文的发表时间）