THE EXPRESSION AND SIGNIFICANCE OF ICAM-1 IN INFLAMMATION OF NERVOUS SYSTEM
Lipopolysaccharid (LPS) is one of the major constituents of the outer membrane of Gram-negative bacteria. It activates monocytes and macrophages to produce cytokines such as TNF- α, IL- 1β, and IL- 6. These cytokines seem to be responsible for the neurotoxicity observed in the peripheral nervous system (PNS) inflammatory disease. It has been reported that in the central nervous system (CNS), intercellular adhesion molecule - 1 (ICAM-1) could be dramatically up-regulated in response to LPS stimulation, as well as many inflammatory cytokines. ICAM- 1 contributes to multiple processes seen in CNS inflammatory disease, for example, migration of leukocytes to inflammatory sites, adhesion of polymorphonuclear cells and monocytes on CNS cells. In the current study, we examined expression and localization changes of ICAM- 1 in various kinds of nerve inflammation processes caused by intraperitoneal and intraspinal injections of LPS to clarity the function of ICAM - 1 in the regulation of never inflammation.
ICAM - 1 LPS, Schwann cell MAPK LFA - 1 Mac- 1
Yang Junling Shen Aiguo Cheng Chun
Department of Medical Experiment Center, Affiliated Hospital Department of Microbiology and Immunolo The Jiangsu Province Key Laboratory of Neuroregeneration Department of Microbiology and Immunology, Medical College, Nantong University,Nantong 226019, China
国际会议
The 6th International Forum on Post-genome Technologies(6IFPT)(第六届国际后基因组生命科学技术学术论坛)
北京
英文
449-454
2009-09-17（万方平台首次上网日期，不代表论文的发表时间）