Genetic Mapping in Human Disease
Genetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.By the eariy 1900s, geneticists understood that Mendels laws of inheritance underlie the transmission of genes in diploid otga-nisms. They noted that some traits are inherited according to Mendels ratios, as a result of altera-tions in single genes, and they developed methods to map the genes responsible. They also recognized that most naturally occurring trait variation, while showing strong correlation among relatives, involves the action of multiple genes and nongenetic factors.
David Altshuler Mark J.Daly Eric S.Lander
Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA Center for Human Genetic Research and D Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA Center for Human Genetic Research and D Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA Department of Systems Biology, Harvard
国际会议
南京
英文
56-63
2009-09-11（万方平台首次上网日期，不代表论文的发表时间）