SUPPRESSION OF OTOTOXICITY BY BAMBOO SALT-PHARMACEUTICAL ACUPUNCTURE
Bamboo salt is a specially processed salt according to the traditional recipe using solar salt and bamboo etc. It has been commonly used for medicinal, skin-care and general health purposes in Korea for more than 1,000 years. Purple bamboo salt (PBS) is the best bamboo salt manufactured through a unique method. We report PBS-pharmaceutical acupuncture prevents the cisplatin-induced ototoxicity. Recent studies have showed that IL-6 expression was distinctively induced in inner ear under various damaging conditions. When PBS was acupunctured at acupoint of triple energiger meridian 21 (TE21) after administration of cisplatin, PBS suppressed the IL-6 production and caspase-3 activation induced by cisplatin in mice cochlear. In addition, PBS inhibits IL-6 production, bcl-2 expression, and extracellular signal-related kinase activation in an auditory cell line, HEI-OCl. Our findings indicate that PBS-pharmaceutical acupuncture may contribute to hearing loss correction.
Purple bamboo salt cisplatin caspase-3 eztracellular signal-related kinase, hearing loss correction
Jae-Young Um Noh-Yil Myung Su-Jin Kim Hong-Kun Rim Hyun-Ja Jeong Seung-Heon Hong Hyung-Min Kim
Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, 130-701 Republic of K Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee Biochip Research Center, Hoseo University, 165, Sechul-ri, Baebang-myun, Asan, chungnam 336-795, Rep College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Iksan, Jeonbuk, 570-7
国际会议
9th International Symposium on Salt(第九届世界盐业大会)
北京
英文
1335-1341
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）