EFFECTS OF MINERAL-RICH SOLAR SALT ON INSULIN RESISTANCE AND INSULIN SIGNALING
Insulin resistance is known to be induced by high-salt consumption. This knowledge comes from researches which used mineral-deficient salts (MDS) such as reagent-grade salt, purified salt and rock salt. Insulin resistance contributes significantly to the pathophysiology of type 2 diabetes mellitus. One mechanism that mediates insulin resistance involves phosphorylation of serine residue in insulin receptor substrate-1 (IRS-1), leading to impaired ability of IRS-1 to degrade insulin signaling pathways. We have investigated whether the effects of mineral-rich solar salt (MRS) on insulin resistance and insulin signaling are different from those of MDS. Male Sprague-Dawley rats were fed diets containing 8％ NaCl of MRS (94％ NaCl) and MDS (more than 99％ NaCl) for four weeks. Our research suggests that MRS intake is preferable to MDS intake in reducing the risk of insulin resistance by improving glucose tolerance and insulin-stimulated glucose uptake. Moreover, MRS group enhanced insulin signaling by diminishing Ser307 phosphorylation of IRS-1 and the expression of NF-κB and IκB that are involved in inflammation compared to MDS group.
mineral-rich salt insulin resistance serine phosphorylation glucose uptake
Ekkapon Lertthanakornkul Tian-Cheng Gao Mi-Ae Bang Jeong-Yong Cho Kyung-Sik Ham
Department of Food Engineering and Solar Salt Biotechnology Research Center, Mokpo National University,Jeonnam 534-729, Republic of Korea
国际会议
9th International Symposium on Salt(第九届世界盐业大会)
北京
英文
1342-1344
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）