MAGNESIUM STATUS AFFECTS NUTRIENT METABOLISM
Magnesium (Mg) is essential for a diverse range of physiological functions and is involved in a variety of the bodys biochemical processes. Mg deficiency, either from inadequate intake or excess excretion, is often suspected to be associated with the development of many symptoms and diseases. The nutritional and physiological importance of Mg has already been well established. In 1952, a positive correlation between the rates of death caused by apoplexy and consumption of hard local drinking water was reported by Kobayashi. Numerous subsequent investigations confirmed that consumption of hard local drinking water decreases hypertension and/or cardiovascular diseases. Mg was finally confirmed to be the most effective element for preventing these diseases. Recently, many studies and meta-analyses, have proved the above finding. Other researchers observed that Mg intake was inversely related to the prevalence of metabolic syndromes. Thus, dietary Mg is important for preventing various lifestyle-related diseases such as hypertension, cardiovascular diseases, and diabetes. Further, a number of studies have reported the effects of Mg deficiency on carbohydrate, lipid, protein, vitamin and mineral metabolism. In the present study, we investigated that the effects of dietary-Mg deficiency on proteins, lipids, ascorbic acid and mineral metabolism including kidney calcification and bone loss in rodents. Furthermore, we performed transcriptome analysis to comprehensively understand the effects of dietary-Mg deficiency in rat liver by using DNA microarray.
Mariko Uehara Tomoko Nemoto Ichiro Matsumoto Shinji Okada Soichi Arai Keiko Abe Shin-ichi Katsumata Kazuharu Suzuki
Department of Nutritional Science, Faculty of Applied Bioscience, and Nodai Research Institue,Tokyo Department of Nutritional Science, Faculty of Applied Bioscience, and Nodai Research Institue,Tokyo Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
国际会议
9th International Symposium on Salt(第九届世界盐业大会)
北京
英文
1484-1488
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）