Particle Morphology: Measurement, Modelling and Closed-loop Control
Organic crystals grown from solution are known to exhibit multiple morphology and habits which are of great importance to the end use properties of the product such as the bioavailability and down stream processing such as in filtration and drying. The crystal morphology can also dictate other quality measures such as size. This paper reviews recent developments in on-line crystal morphology measurement and control using on-line imaging and image analysis. On-line imaging was found to be able to capture with high fidelity crystal shape and polymorphic transitions in real-time. The images were analyzed using a multi-scale image analysis method to extract the crystals from the image background. Preliminary results on estimating crystal growth rates and kinetics parameters for different facets for rod-like crystals were presented. The paper also reviewed recent developments in morphological population balance (PB) modelling which can provide the evolution of the shape and distributions of sizes in all crystal face directions in a reactor. Finally, a methodology for closed-loop control of crystal morphology is presented.
Particle morphology Imaging Image analysis Population balance model Particle shape control
Xue Z.Wang
Institute of Particle Science and Engineering, University of Leeds, Leeds LS2 9JT
国际会议
沈阳
英文
217-221
2009-08-27（万方平台首次上网日期，不代表论文的发表时间）