Analysis on the Effect of Natural Cerebrolysin on Gene Ezpression Profile of Hippocampus in Rat AD Model by Whole Genome Microarray and Bioinformation Technologies
Objective: By analyzing the effect of natural cerebrolysin (NC) on gene expression profile of rat hippocampus Alzheimers disease (AD), to explore its molecular genetic pharmacodynamic mechanism of anti-AD. Methods: The experiment included the AD model, sham-operation and NC treated group. The changes of hippocampus gene expression profiles in the above three groups were analyzed by Affymetrix rat whole genome expression profile microarray. Results: Compared to the sham-operation group, the AD model group had 50 up-regulated genes (Fold Change>2)and 21 down-regulated genes(Fold Change <0.5) with significant difference. Compared to the model group, the NC treated group was found to have 5 up-regulated genes and 20 down-regulated genes with significant difference. Conclusion: NC can regulate hippocampal function, and further regulate the brain function of animals in multiple gene target points by a number of ways.
whole genome genome microarray gene ezpression profile Natural cerebrolysin (NC) Alzheimers disease (AD) hippocampus
LI Ying-hong WU Zheng-zhi LI Ming JIA Xiu-qin YANG Min CHEN Man-yin
The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong
国际会议
2009 IEEE International Symposium on IT in Medicine & Education( IEEE 教育与医药信息化国际会议)
济南
英文
38-49
2009-08-14（万方平台首次上网日期，不代表论文的发表时间）