Preliminary Study of Salivary Proteome on the Diagnosis for Discrimination of Gastric Cancer and Chronic Gastritis

摘要：

Objective: To investigate and seek the special biomarkers of the salivary protein expression profile for the discrimination diagnosis between gastric cancer and chronic gastritis. Method: The saliva collected were detected by applying WCX magnetic beads and using MALDI-TOF-MS technique. Corresponding peptide mass fingerprint was obtained and differential diagnostic cast was developed. Result: Differences in 77 protein peaks were observed from chronic gastritis and gastric cancer patients. One protein peak among them presented statistical significant difference (p<0.05). Predictive model for discrimination of gastric cancer and chronic gastritis was developed. Its identification rate was 83.54％, and its capability of predication was 60.23％. Conclusion: The protein expression profile of saliva collected from gastric cancer and chronic gastritis patients was preliminarily obtained. The diagnostic cast for discrimination of the two diseases was classified by the expression of molecular weight 6021.72Da protein.

关键词： proteomics bioinformatics chronic gastritis gastric cancer diagnostic cast saliva MALDI-TOF-MS

作者: WU Zheng-zhi WANG Ji-guo ZHANG Xiao-li CAO Mei-qun

作者单位: The First Affiliated Hospital of Shenzhen University (Shenzhen, Guangdong 518035

会议类型: 国际会议

会议名称: 2009 IEEE International Symposium on IT in Medicine & Education( IEEE 教育与医药信息化国际会议)

会议地点: 济南

会议语种:英文

页码: 70-75

在线出版日期: 2009-08-14（万方平台首次上网日期，不代表论文的发表时间）