Conceptus-endometrial interactions: mechanistic insights and implications for animal health and nutrition
This review provides insight into conceptus-uterine interactions in ruminants with emphasis on the peri-implantation stage of pregnancy and implications for animal health and nutrition. Conceptus-endometrial interactions in ruminants are complex and involve carefully orchestrated temporal and spatial alterations in endometrial gene expression that are regulated by factors from the ovary (progesterone) and conceptus (interferon tau or IFNT and chorionic somatomammotropin one or CSH1). The coordinate, interactive, and cell-specific effects of progesterone, IFNT, and/or CSH1 on the endometrium provide for transport of specific nutrients that modulate conceptus growth and differentiation via effects on trophectoderm proliferation, migration, attachment and adhesion. It is now well-recognized that nutrition of the developing conceptus impacts growth, metabolism, gene expression, and physiology of the fetus, neonate and adult. Thus, research in this area is important to development of new strategies for ameliorating disease (infertility and pregnancy loss), improving pregnancy outcome and reproductive efficiency, and ensuring the long-term health and well-being of offspring in domestic animals, as well as humans.
T.E.Spencer F.W.Bazer G.A.Johnson R.C.Burghardt G.Y.Wu
Departments of Animal Science College Station, Texas 77843-2471, USA Veterinary Integrative Bioscien Veterinary Integrative Biosciences2, Texas A&M University,College Station, Texas 77843-2471, USA
国际会议
4th International Symposium on Animal Nutrition,Health and Feed Additive(第四届动物营养、保健与饲料添加剂国际学术研讨会)
广州
英文
96-104
2009-07-04（万方平台首次上网日期，不代表论文的发表时间）