Application of Biochip and Bionano Sensing Technology for Detection of Bioactivity and Harmful Substances in Organism
Nano materials such as gold, silver nanoparticles and carbon nanotubes (CNTs) have attracted much attention over the past decade due to their diminutive size and novel material properties 1, 2. Their nanometer scale size made them suitable for many new applications with different properties concerning the bulk materials 3, especially exhibited a strong UV-Vis absorption signals which could be used as a non-labeling sensing method for biomolecular interactions 4, like localized surface plasmon resonance (LSPR). LSPR is well known in physics that the incident photon frequency is resonant with the collective oscillation of the spatially confined conduction electrons on a noble metal nanoparticle 5. In comparison with several reported label-free biosensors based on surface plasmon resonance 6 and quartz crystal microbalance 7, the LSPR nanosensor based on nanoparticle size and shape could yield ultrasensitive bio-detection with extremely simple, small, light, robust, and low-cost instrumentation 8. In this paper, novel optical biochips assembled with various nano materials like gold and silver nanoparticles on Au surface has been constructed for detection of bioactive and harmful substances in organism like antibody-antigen protein, DNA oncogene molecules.
Z.Cao Y.L.Yin
School of Chemistry and Biological Engineering, Changsha University of Science andTechnology, Changs Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, P.R.China
国际会议
4th International Symposium on Animal Nutrition,Health and Feed Additive(第四届动物营养、保健与饲料添加剂国际学术研讨会)
广州
英文
506-507
2009-07-04（万方平台首次上网日期，不代表论文的发表时间）