Aberrant ezpression of human sperm protein 17 influence biological behaviors of ovarian cancer cells
Human sperm protein 17 has been demonstrated previously a normal testicular proteins aberrantly expressed in neoplastic cells. In the current study, we investigated the aberrant expression of human sperm protein 17(HSp17) in human epithelial ovarian cancer cells and tried to analyze its influences on the cell behaviors, especially cell migration and chemoresistance, by introducing HSp17 cDNA into a human ovarian carcinoma cell line HO8910. Overexpression of HSp17 increased the migration but decreased the chemosensitivity of ovarian carcinoma cells to carboplatin and cisplatin. The results strongly suggest that HSp17 plays a role in metastatic disease and resistance of epithelial ovarian carcinoma to chemotherapy.
epithelial ovarian cancer sperm protein 17 migration chemoresistance
Li Fang-Qiu Han Yan-Ling Liu Qun Zhang Shi-Xin
Institute of Medical Laboratory Sciences, Nanjing Jinling Hospital, Medical School, Nanjing University, Nanjing, 210002, China
国际会议
International Symposium on Medical and Pharmaceutical Biotechnology(医药生物技术国际研讨会)
南京
英文
8-11
2009-04-27（万方平台首次上网日期，不代表论文的发表时间）