Adenosine induces G2/M cell-cycle arrest by inhibiting cell mitosis progress
Adenosine is the product of ATP degradation when cell undergoes various stresses, and many researches focus on the anti-inflammation of adenosine. Few papers about adenosine concern cell cycle. Cell cycle is the essential mechanism by which all living lives reproduce and it is also one key regulatory target machinery when cells encounter stresses, so it is necessary to examine the detail relationship between adenosine existence and cell cycle. In the present study, adenosine was found to induce G2/M cell-cycle arrest. Furthermore, adenosine was found to modulate the expression of some cell cycle decisive proteins such as cyclin B and p21, the phosphorylation of CDC2, and thus inhibit the transition of metaphase to anaphase of mitosis.
adenosine cell cycle mitosis cyclin B cdc2
Jia Kun-Zhi Tang Bo Yu Lu Cheng Wei Zhang Rong Zhang Jian-Fa Hua Zi-Chun
Jiangsu Center of Hepatobiliary Diseases, the State Key Laboratory of Pharmaceutical Biotechnology, Center for Molecular Metabolism, School of Life Science, Nanjing University, Nanjing, 210093, China
国际会议
International Symposium on Medical and Pharmaceutical Biotechnology(医药生物技术国际研讨会)
南京
英文
12-14
2009-04-27（万方平台首次上网日期，不代表论文的发表时间）