HCV F protein, a protein correlating with HCV pathogenesis

摘要：

In addition to the 10 gene products, Hepatitis C virus (HCV) produces a novel protein, known as F protein. F protein is encoded by an open reading frame (ORF) that overlaps the core gene in the+1 frame (core+1 ORF). In an attempt to understand the biological functions of the F protein, we have expressed the alternative HCV core protein, a+1 frameshifting at codon 42 followed by a rephasing in the normal open reading frame at stop codon 144, from the genotype 1b are expressed in E. coli. We demonstrate that the expression of HCV-1b F protein using Weastern blotting and is regulated by HCV core protein expression. Further, we show that F protein is correlated with the HCV pathogenesis. Thus, F protein may intimately linked to the molecular pathogenesis in HCV-infected individuals.

关键词： F protein HCV 1b subtype pathogenesis

作者: Kong Jing Deng Xiao-Zhao Wang Zhong-Chan Zhang Yun Yang Jing-Jing

作者单位: Huadong Research Institute for Medicine and Biotechniques, Nanjing, 210002, China

会议类型: 国际会议

会议名称: International Symposium on Medical and Pharmaceutical Biotechnology(医药生物技术国际研讨会)

会议地点: 南京

会议语种:英文

页码: 99-102

在线出版日期: 2009-04-27（万方平台首次上网日期，不代表论文的发表时间）