Genetic polymorphisms of metabolizing enzymes related to chemotherapy drugs in breast cancer and their clinical significance
(0) Background and Objective: The sequencing of the human genome has allowed the identification of thousands of gene polymorphisms, most often single nucleotide polymorphims (SNP), which play an important role in the expression level and activity of the corresponding proteins. In the case of breast treatment, SNPs may be related to different therapeutic responses and/or adverse effects. The identification of related SNPs and research of their association with efficacy will provide useful information for tailored therapy of breast cancer. This study aimed to explore the SNPs in genes of drug-metabolizing enzymes and to evaluate their potential effects on treatment outcomes in breast cancer patients who received TAC/FCA regimen chemotherapy.
breast cancer chemotherapy response genotyping metabolism enzyme genes polymorphism
Jinhai Tang
Jiangsu Cancer Hospital
国际会议
上海
英文
32-33
2008-10-01（万方平台首次上网日期，不代表论文的发表时间）