Protection From High Dose Chemotherapy By Transduced With Double-Mutant Dihydrofolate Reductase-Cytidine Deaminase Genes Into Mice bone marrow cells

摘要：

Background and Aim:Drug resistance gene (genes) transfer could increase the tolerance of bone marrow cell to chemotherapeutic agents. We transferred fusion drug resistance genes of DHFR gene and CD gene into mouse bone marrow cells to explore the feasibility of the tolerance of myelosuppression following combination chemotherapy and improve the clinical efficiency. The protection of bone marrow with the genes would allow larger and curative doses of high dose MTX and Ara-C.

关键词： Dihydrofolate Reductase Cytidine Deaminase Methotrezate Cytosine Arabinoside

作者: Caigang liu Bo Chen Fan Yao Ping Lu Feng Jin

作者单位: Department of breast surgery, the first hospital of China Medical University.Shenyang, Liao Ning, China, 110001

会议类型: 国际会议

会议名称: 15th World Congress on Breast Disease and 3rd Shanghai Breast Cancer Symposium(第十五届国际乳腺病大会暨第三届上海国际乳腺癌论坛)

会议地点: 上海

会议语种:英文

页码: 148-151

在线出版日期: 2008-10-01（万方平台首次上网日期，不代表论文的发表时间）