Protection of a cytidine deaminase gene gainst tozicity of high dose chemotherapy in mice

摘要：

Background and Aim:To explore the feasibility of transferring cytidine deaminase (CD) gene into mouse bone marrow cells in order to observe the drug resistance of high dose Ara-C and improve the tolerance of myelosuppression following combination chemotherapy. Methods:1 Separation of vectors and drug resistance genesThe retrovirus vectors containing drug resistance genes SFG-CD (containing human mutant Cytidine Deaminase, mCD) was transduced into amphotropic packaging cell (GP-Am12, Am12), and constructed AM12-SFG-CD. These vectors and cell lines were kindly provided by professor Shicheng Zhao (MSKCC).

关键词： Cytidine deaminase Gene therapy Ara-C

作者: Caigang liu Bo Chen Fan Yao Ping Lu Feng Jin

作者单位: Department of breast surgery, the first hospital of China Medical University.Shenyang, Liao Ning, Ch Department of breast surgery, the first ospital of China Medical University.Shenyang, Liao Ning, Chi

会议类型: 国际会议

会议名称: 15th World Congress on Breast Disease and 3rd Shanghai Breast Cancer Symposium(第十五届国际乳腺病大会暨第三届上海国际乳腺癌论坛)

会议地点: 上海

会议语种:英文

页码: 152-154

在线出版日期: 2008-10-01（万方平台首次上网日期，不代表论文的发表时间）