The ezpression of COX-2 and TRX-1 in breast cancer and the correlation with prognosis
Introduction:Many studies indicated that over-expression of cyclooxygenase-2 (COX-2) was correlated with occurrence and development of many solid cancers (such as colorectal cancer, lung cancer, ect.). Over-expression of COX-2 protein in cancers was likely to occur via several different mechanisms involving complex signaling pathways. Over-expression had been associated with a poor clinical outcome. High incidence rates of over-expression COX-2 was also found in breast cancer patients. At present although we used selective inhibitor to improve prognosis, the angiomyocardiac adverse effect constrained the serviceable range. Furthermore the curative effect was not sure. So if we could inhibit expression of upstream control factors, it would be better for downregulation of COX-2. But now the mechanism of regulation was not clear.
Thioredozin-1(TRX-1) Cycloozygenase-2(COX-2) Breast cancer Disease Free Survival Time(DFS)
Zhang Yan Teng Yue-e Bu Xin Song Ming Liu Yun peng Hou K.e zuo
Department of Medical Oncology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
国际会议
上海
英文
161-163
2008-10-01（万方平台首次上网日期，不代表论文的发表时间）