IN VITRO AND IN VIVO BIOCOMPATIBILITY STUDIES OF ZNO NANOPARTICLES

摘要：

The in vitro and in vivo biocompatibility of the ZnO nanoparticles were evaluated using cell model and animal model, by MTT assay, flow cell cytometry, pathological optical and electron microscopy examinations. Both the L929 cell and Hela cell proliferative activity were strongly inhibited by the presence of ZnO nanoparticles, no matter cultured with low dose and high dose suspension. AnnexinV-FITC/PI-FCM assay showed that the number of necrotic cell and apoptotic cell increased significantly. Feeding the ZnO nanoparticle suspension through digestive tract would lead to the damage to some primary organs (heart, lung, liver and kidney). Further investigation by TEM showed the expanded sarcoplasmic reticulum and organdie vacuolation features.

关键词： ZnO biocompatibility cell proliferation apoptosis

作者: YUFENG ZHENG RANZHONG LI YUEDAN WANG

作者单位: Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, No.5 Department of Immunology, School of Basic Medicine, Peking University, No.38, Xue-Yuan Road, Beijing

会议类型: 国际会议

会议名称: 第五届先进材料与加工国际会议(Fifth International Conference on Advanced Materials and Processing ICAMP-5)

会议地点: 哈尔滨

会议语种:英文

页码: 1566-1571

在线出版日期: 2008-09-03（万方平台首次上网日期，不代表论文的发表时间）