A Molecular Picture of Seasonal Influenza

摘要：

In this talk we review a biophysical method for prediction of transcription factor affinity to binding sites on the DNA. The affinity prediction is calibrated to reproduce ChiP-chip values where these are available, while also allowing for prediction solely based on a weight matrix description of a binding site. We also computed statistics for the significance of the affinity values, which allows comparing predicted binding behavior of different factors. Further, we computed tissue specific transcription factors by analyzing promoters from sets of tissue specific genes. Results confirm established knowledge and provide several new predictions.

作者: Martin Vingron

作者单位: Max Planck Institute for Molecular Genetics, Computational Molecular Biology Department, Computer Science, Free University of Berlin, Germany

会议类型: 国际会议

会议名称: The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)

会议地点: 北京

会议语种:英文

页码: 11

在线出版日期: 2009-01-01（万方平台首次上网日期，不代表论文的发表时间）