Comparative analysis of the JAK/STAT signaling through erythropoietin receptor and thrombopoietin receptor using a systems approach
(0) Background: The Janus kinase-signal transducer and activator of transcription (JAK/STAT)pathway is one of the most important targets for myeloproliferative disorder (MPD). Although several efforts toward modeling the pathway using systems biology have been successful, the pathway was not fully investigated in regards to understanding pathological context and to model receptor kinetics and mutation effects.Results: We have performed modeling and simulation studies of the JAK/STAT pathway, including the kinetics of two associated receptors (the erythropoietin receptor and thrombopoietin receptor) with the wild type and a recently reported mutant (JAK2V617F) of the JAK2 protein.Conclusions: We found that the different kinetics of those two receptors might be important factors that affect the sensitivity of JAK/STAT signaling to the mutation effect. In addition, our simulation results support clinically observed pathological differences between the two subtypes of MPD with respect to the JAK2V617F mutation.
Hong-Hee Won Inho Park Eunjung Lee Jong-Won Kim Doheon Lee
Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, 373-1 G Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, 373-1 G Department of Laboratory Medicine and Genetics, Sungkyunkwan University School of Medicine, Samsung
国际会议
The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)
北京
英文
599-606
2009-01-01（万方平台首次上网日期，不代表论文的发表时间）