De Novo Ezon Acquisition during Human Evolution

摘要：

BackgroundHumans have acquired many distinct features compared to chimpanzees and other great apes 1.Gain of such human-specific traits must be initiated and consolidated by successive genetic changes and natural selection. We developed a hioinformatics method for systematic identification of the human exons that had been introduced after the divergence of humans and chimpanzees.Data & MethodsFirst, we collect genomic fragments that are only present in the human genome compared to the chimpanzee and the rhesus macaque genomes by analyzing the UCSC Genome Browser Database 2. Then, we check whether the newly inserted fragment includes the sequence of an exonic region of the human spliced transcripts.

作者: Yoonsoo Hahn Byungkook Lee

作者单位: Department of Life Science, Chung-Ang University, Seoul 156-756, South Korea Laboratory of Molecular Biology, NCI, NIH, Bethesda, Maryland 20892, USA

会议类型: 国际会议

会议名称: The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)

会议地点: 北京

会议语种:英文

页码: 825

在线出版日期: 2009-01-01（万方平台首次上网日期，不代表论文的发表时间）