The evolution rate speed-up event of UCP1 indicates the essential residues for its characteristic high uncoupling activity

摘要：

BackgroundUncoupling Protein (UCP) 1 is a transmemebrane protein located in the mitochondrial inner membrane of brown adipose tissue. It belongs to a mitochondrial transporters family that regulates proton leak and discharges of the proton gradient generated by the respiratory chain (see Fig. I).UCPl presents a high uncoupling activity that is a unique property of this carrier whose homologues in the same family, UCP2 and UCP3, do not have. This mechanism of energy dissipation is used by Eutheria to maintain their body temperature when exposed to long term cold environment.But the exact mechanism of UCP 1 s high uncoupling activity is still unclear. Recently, there are some nonfunctional UCP1 discovered in ectothcrm. This is a confused but interesting phenomenon which would help to understand UCP 1 s structure and function relationship

作者: Yaping Liu Kun Chen Zhiyuan Lv Hongxiang Zheng Jin Wang Chenyu Zhang

作者单位: State Key laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China

会议类型: 国际会议

会议名称: The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)

会议地点: 北京

会议语种:英文

页码: 831

在线出版日期: 2009-01-01（万方平台首次上网日期，不代表论文的发表时间）