Prevalent use of bidirectional promoters generates pervasive transcription in veast
BackgroundGenome-wide pervasive transcription has been reported in many eukaryotic organisms 1, revealing a highly interleaved transcriptome organization that involves hundreds of novel noncoding RNA. These recently identified transcripts either exist stably in cells (Stable Unannotated Transcripts) or are rapidly degraded by the RNA surveillance pathway (Cryptic Unstable Transcripts). One characteristic of pervasive transcription is the extensive overlap of SUTs and CUTs with previously annotated features, which prompts the questions of how these transcripts are generated, and whether they exert function.Single gene studies have shown that transcription of both SUTs and CUTs can be functional,through either mechanisms involving the generated RNAs or their generation itself. To date, a complete transcriptome architecture including CUTs and SUTs has not been described in any organism. Knowledge about the position and genome-wide arrangement of these transcripts will be instrumental in understanding their function.
Zhenyu Xu Wu Wei Julien Gagneur Lars M.SteinmetzS
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
国际会议
The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)
北京
英文
843
2009-01-01（万方平台首次上网日期，不代表论文的发表时间）