Genome-wide identification of TSS, promoters and transcriptional factor binding sites in E. coli K-12 bacterial genome: Development of a bioinformatics tool for the graphical display of the high throughput sequencing data
BackgroundGene expression starts by the specific and normally tightly regulated transcription initiation process. The accurate mapping of Transcription Initiation Sites (TSS) has been accomplished in a operon-specific basis using laborious biochemical techniques. Currently,more than 1200 TSSs have been experimentally mapped, according to RegulonDB (http://regulondb.ccg.unam.mx). TSSs determination is critical to unambiguously identify promoters and regulatory regions controlling gene expression. Having precise information about the majority of the TSSs in E. coli will certainly help to achieve a detailed understanding of the global regulatory circuits that control gene expression in this very important model organism.
Enrique Morett Leticia Vega-Alvarado Ryosuke L.A.Watanabe Edgar E.Vallejo Alfredo Mendoza Leticia Olvera Maricela Olvera Katy Juárez Bruno Contreras Verónica Jiménez Julio Collado-Vides Blanca Taboada
Instituto de Biotecnologta, Universidad Nacional Autonoma de Mexico, Mexico Centro de Ciencias Aplicadas y Desarrollo Tecnologico, Universidad Nacional Autonoma de Mexico, M Instituto Tecnologico y de Estudios Superiores de Monterrey, Campus Estado de Mexico, Mexico Centro de Ciencias Genomicas, Universidad Nacional Autonoma de Mexico, Mexico
国际会议
The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)
北京
英文
844
2009-01-01（万方平台首次上网日期，不代表论文的发表时间）