Prediction of translation initiation site for microbial genomes

摘要：

BackgroundAccurate prediction of translation initiation site (TIS)is crucial for the predictions of operon, promoter,signal peptide and small noncoding RNAs.Remarkable progress has been made recently, but there still exists two limitations: 1) most methods involve a number of assumptions about TIS-related features, and consequently parameters optimized for some genomes are sub-optimal for others 1, and 2)the prediction performance is found to show some degree of dependence on the set of initial annotation2. Here, we report a new method that overcomes the two limitations.

作者: Gang-Qing Hu Xiaobin Zheng Huaiqiu Zhu Zhen-Su She

作者单位: State Key Laboratory for Turbulence and Complex Systems and Department of Biomedical Engineering, and Center for Theoretical Biology Peking University, Beijing, 100871, China

会议类型: 国际会议

会议名称: The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)

会议地点: 北京

会议语种:英文

页码: 845

在线出版日期: 2009-01-01（万方平台首次上网日期，不代表论文的发表时间）