Chromatin modification similarity and coezpression of neighboring gene pairs in yeast
BackgroundNeighboring genes in yeast genome have a tendency of coexpression. The similar chromatin regulation was considered as the main source responsible for such coexpression. However, there is no directly evidence to illuminate the contribution of chromatin regulation to coexpression of neighboring genes.Data & MethodsWe used chromatin modification similarity (CMS)defined as Pearson Correlation Coefficient (R) of gene histone modification profiles1-2 to evaluate the similarity of chromatin regulation, and investigated whether neighboring genes had a higher CMS than random, and then analyzed the contribution of CMS to expression similarity (ES) defined as mean R of expression profile in 23 expression datasets. Furthermore, the contribution of combination of CMS and transcription control similarity (TCS) defined as the R of binding ratio profiles 3 to such coexpression was also analyzed.
Yangyang Deng Xianhua Dai Qian Xiang Caisheng He Jiang Wang Jihua Feng Zhiming Dai
School of Information Science and Technology, Sun Yat-Sen University, 135 West Xingang Road, Guangzhou, PR China
国际会议
The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)
北京
英文
848
2009-01-01（万方平台首次上网日期，不代表论文的发表时间）