A comparison study of cross-platform ezperimental nucleosome positioning data: a nucleosome statistical distribution domain model in the S. cerevisiae genome
BackgroundWith a number of high-resolution genome-wide maps of nucleosome positions published, we sought to address the following questions: (1) How to extract the agreement and disagreement between the crossplatform experimental data in an effective way? (2)Whether this cross-platform information can faithfully reflect the mechanism of nucleosome packaging in vivo? (3) What is relationship between these five studies and nucleosome characteristics, such as fuzzy and well-positioned distributions? And (4) whether the agreement and disagreement between the different studies are associated with gene architecture and chromatin state, such as histone modification and turnover?Data & MethodsIn this study, all nucleosome positions data sets,TFBs PWM, DNA bendability, histone modifications and turnover rate are obtained for corresponding studies or their web sits. Finally, all signals were aligned by the TSS of 5,015 high-confidence transcripts derived from the literature 1.
Jihua Feng Xianhua Dai Qian Xiang Zhiming Dai Jiang Wang Yangyang Deng Caisheng He
School of Information Science and Technology, Sun Yat-Sen University, 135 West Xingang Road, Guangzhou, PR China
国际会议
The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)
北京
英文
849
2009-01-01（万方平台首次上网日期，不代表论文的发表时间）