Recovering gene regulations by optimization model

摘要：

BackgroundWith rapid advances of various highthroughput experimental techniques, more and more biological data are increasingly available. It is now possible to quantitatively study regulatory interactions in a systematic way and there is also a pressing need for the development of sophisticated algorithms for reverse-engineering gene networks. Generally speaking, there are three kinds of regulatory relationships among the regulators (transcriptional factors and cofactors) and target genes,I.e. The relationships between target genes, the relationships between regulators, and the relationships between regulators and target genes. To identify these three relationships,we proposed several optimization models to reveal regulatory mechanisms.

作者: Yong Wang Xiang-Sun Zhang Luonan Chen

作者单位: Academy of Mathematics and Systems Science, CAS, Beijing 100190, China Department of Electronics, Information and Communication Engineering, Osaka Sangyo University, Osaka

会议类型: 国际会议

会议名称: The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)

会议地点: 北京

会议语种:英文

页码: 854

在线出版日期: 2009-01-01（万方平台首次上网日期，不代表论文的发表时间）