Characteristic analysis of miRNA precursors in metazoan species

摘要：

BackgroundMiRNAs are a class of important endogenous noncoding RNAs that play important roles in posttranscriptionai regulation of gene expression. Characteristics are essential to miRNAs identification. However,only a few studies are reported on miRNA features1-3. Here, we analyze all experimentally validated metazoan pre-miRNAs comparing with other RNAs including tRNAs, rRNAs and mRNAs.Materials and methods2729 pre-miRNAs downloaded from the miRBase database are compared with 350 tRNAs, 140 RNAs and 500 mR.Nas from metazoan species. Secondary structures of pre-miRNAs are classified into two types: Type I with only one hairpin loop, and Type Ⅱ containing multiple loops. Statistical analysis is executed separately on each type of RNAs at the level of primary sequences and secondary structures, where the mMFE is a new criterion proposed in our study.

作者: Xiaobai Zhang Xiaofeng Song Huinan Wang Huanping Zhang

作者单位: Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 2 Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 2

会议类型: 国际会议

会议名称: The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)

会议地点: 北京

会议语种:英文

页码: 856

在线出版日期: 2009-01-01（万方平台首次上网日期，不代表论文的发表时间）