The microRNAseffects on the ezpression of target genes at mRNA and protein levels

摘要：

BackgroundMicroRNAs (miRNAs), well known as posttranscriptional regulator, can regulate gene expression by binding to the 3 untranslated regions (3UTRs) of their target mRNAs 1. There are two mechanisms of miRNA-mediated repression: mRNA degradation and translational repression. So far, it is still unclear what determine the ways of miRNA-mediated repression of target genes. Majority of current studies to explore the mechanisms of miRNA-mediated repression only depends on analyzing single level of the gene expression data of target genes, either on microarray or proteomic profiles 2. Moreover, it is necessary to combine the expression level of miRNA itself with the target genes to detect the mechanisms.

作者: Yunfei Pei Xi Wang Xuegong Zhang

作者单位: MOE Key laboratory of Bioinformatics and Bioinformatics Division, TNLIST / Department of Automation, Tsinghua University, Beijing 100084, China

会议类型: 国际会议

会议名称: The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)

会议地点: 北京

会议语种:英文

页码: 857

在线出版日期: 2009-01-01（万方平台首次上网日期，不代表论文的发表时间）