Protein Function-Function Correlation Approach for Protein Functions Prediction

摘要：

BackgroundAssigning functions to novel proteins is one of the most important problems in proteomic study, and many methods have been developed to assign functions to an unknown protein. Most of the methods developed to infer protein functions have many parameters, so it hindered these modelsapplications in practice.Data & MethodsThe computational method we considered, the socalled protein function pair approach, is carried forward from the protein domain pair approaches 1,2, with protein functions substituted for protein domains in the present study. In our formulation, Kim et al. approach is modified by incorporating a randomization procedure in order to assign functionfunction correlation score for a protein function pair,which could facilitate protein function prediction.

作者: Ka-Lok Ng Chien-Hung Huang Jin-Shuei Ciou

作者单位: Department of Bioinformatics, Asia University, 500 Lioufeng Road, Wufeng Shiang, Taichung, Taiwan 41 Department of Computer Science and Information Engineering, National Formosa University, 64,Wen-Hwa

会议类型: 国际会议

会议名称: The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)

会议地点: 北京

会议语种:英文

页码: 872

在线出版日期: 2009-01-01（万方平台首次上网日期，不代表论文的发表时间）