Detecting protein structure flezibility via rigid structure identification
Motivation and backgroundTo detect the flexible region in protein structure is an important step to locate the sequence or regional structures related to the function of protein. Previous researches give us guidance that the stability and flexibility are coexistence in protein structure 1, 2. Conventional approaches use global structure alignment tool to reveal the structure variations, which provide messy information about flexible regions.ApproachesWe investigate in the variant structures of the same sequence, and propose a new method to detect the stable and flexible regions from protein structures. Our assumption is that protein structure contains highly stable regional structure to support its protein function, which can be used to detect other flexible regions of the same protein. Therefore, this proposed approach is to detect stable regions via mining frequent itemset method and local structure encoding scheme for fast search on similar local structure. Furthermore, the flexible part of protein can be detected by identifying rigid structural region of proteins.Materials for this framework are collected highresolution structure variations of protein examined by X-ray crystallization.
Yu-Feng Huang Chia-Jui Yang Chun-Chin Huang Chien-Kang Huang Chun-Yi Huang Li-Yuan Chiu Pei-Chun Ko Chiun-Yao Chiang
Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiw Department of Engineering Science and Ocean Engineering, National Taiwan University, Taipei, Taiwan
国际会议
The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)
北京
英文
876
2009-01-01（万方平台首次上网日期，不代表论文的发表时间）