Computational characterisation of human lamina associated domains

摘要：

BackgroundFor about 50 years, scientists have wonderedhow two metres of DNA are organised inside ahuman cell nucleus of approximately 10mm indiameter. It was speculated that the nuclearlamina, a protein shell surrounding the nuc-lear interior, acts as a scaffold that organisesthe DNA. Our recent study 1 identified>1000 very large (0.1-10Mb), sharply definedsegments of the human genome that are at-tached to the lamina, termed lamina asso-ciated domains (LADs).

作者: Wouter Meuleman Ludo Pagie Marcel Reinders Bas van Steensel Lodewyk Wessels

作者单位: Departments of Molecular Biology and Gene Regulation, The Netherlands Cancer Institute, Amsterdam, T Departments of Molecular Biology and Gene Regulation, The Netherlands Cancer Institute, Amsterdam, T Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology,

会议类型: 国际会议

会议名称: The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)

会议地点: 北京

会议语种:英文

页码: 878

在线出版日期: 2009-01-01（万方平台首次上网日期，不代表论文的发表时间）