Protein Maps: Integration of Physico-Chemical Properties for Functional Annotation of Proteins

摘要：

BackgroundThe contribution of conserved residues toward biochemical function is determined by the interactions formed with substrates, cofactors, and other residues.We thus hypothesize that correlated mutations of physico-chemical (sequence based properties) interactions between residues reveal evolutionary residue conservation patterns that are unique to homologous proteins. In this poster, we report a unique representation scheme, protein maps for a given protein. The protein maps are aimed at capturing structural makers across a myriad of physico-chemical properties. We have used a wavelet-based analysis and reported regions of functional significance in the protein. We have carried out and reported further validations which support our study.

作者: Sumeet Dua Pradeep Chowriappa

作者单位: Data Mining Research Laboratory, Computer Science Program, Louisiana Tech University, Ruston, LA -71270

会议类型: 国际会议

会议名称: The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)

会议地点: 北京

会议语种:英文

页码: 882

在线出版日期: 2009-01-01（万方平台首次上网日期，不代表论文的发表时间）